Many diseases and disease symptoms still lack effective treatment. At the same time, certain controversial Schedule I drugs, such as heroin and cannabis, have been reputed to have considerable therapeutic potential for addressing significant medical problems. Yet, there is a paucity of U.S. clinical studies on the therapeutic uses of controlled drugs. For example, people living with HIV/aids experience a variety of disease- and medication-related symptoms. Their chronic pain is intense, frequent, and difficult to treat. Nevertheless, clinical trials of compassionate (...) management for their chronic symptoms, which should be a research priority, are stymied. Stakeholders’ Views on Barriers to Research on Controlled Substances Evelyn Rhodes, Michael Andreae, Tyler Bourgiose, Debbie Indyk, Rosamond Rhodes, and Henry Sacks We employed qualitative methods to develop an understanding of the barriers to research on potential therapeutic uses of Schedule I drugs so that they might be addressed. We elicited the perspectives of key stakeholder groups that would be involved in such studies: people living with HIV/aids, clinicians, and members of institutional review boards. As we identified obstacles to research, we found that all of the stakeholder groups arrived at the same conclusion, that clinical research on the therapeutic potential of these drugs is ethically required. (shrink)

Book reviewed in this article: The Man Who Mistook His Wife for a Hat and Other Clinical Tales. By Oliver Sacks.

This essay shows that some recent work by George Weaver can be reformulated in an especially perspicuous way within the theory of closure systems. Closure theoretic generalizations of some theorems of Robert Goldblatt are presented. And, more generally, the relation between closure systems and the deducibility relations of Goldblatt is explored.

This book explores the complex nexus of discourses, principles and practices within which educators mobilise school-based health education. Through an interrogation of the ideas informing particular models and approaches to health education, the authors provide critical insights into the principles and practices underpinning approaches to health education policy, curriculum, pedagogy and assessment. Drawing on extensive literature and research, the book explores and considers what health education can and should do. Chapters examine the extent to which health education, past and present, (...) has attended to the needs and interests of young people in school environments, as well as assess common pedagogical approaches and whether the outcomes tally with expectations. By considering the problems in teaching health education, curriculum making, health education pedagogies and porous classrooms, the book offers a knowledge base from which educators can consider how theories and models can sit together to shape curriculum and influence practice. School Health Education in Changing Times will be of key interest to postgraduate students, researchers and academics in the field of health education. It will also be a valuable resource for teacher educators, current teachers, and those on professional development courses who want to navigate the moral minefield surrounding health education. (shrink)

Journal Name: Semiotica - Journal of the International Association for Semiotic Studies / Revue de l'Association Internationale de Sémiotique Volume: 2013 Issue: 196 Pages: 243-260.

CarloCellucci. Rethinking Knowledge: The Heuristic View. Cham, Switzerland: Springer International Publishing, 2017. ISBN 978-3-319-53236-3, 978-3-319-53237-0. Pp. xx + 428††.

The expressive truth functions of two-valued logic have all been identified. This paper begins the task of identifying the expressive truth functions of n-valued logic by characterizing the unary ones. These functions have distinctive algebraic, semantic, and closure-theoretic properties.

School connectedness is the leading protective factor against multiple at-risk behaviors for adolescents. Its far-reaching influence, however, is not widely known. This book provides valuable information about school connectedness, including strategies on how to strengthen life-saving ties with students.

The paper begins by distinguishing between two ways of effecting the dissolution of a philosophical problem: reductive and philosophical. Of these, the former holds out deflationary prospects greater than those of the latter. Attention focuses specifically on McGinn's proposed dissolution of the mind‐body problem. Examination of his argument reveals that his naturalist dissolution involves traditional non‐naturalist constraints, in a way that counts against his deflationary conclusions. At best his treatment constitutes a philosophical, rather than a reductive dissolution. But there is (...) reason to think that it might in fact constitute a mere relocation of what is, essentially, the same problem that it set out to dissolve. (shrink)

Even though considerable resources have been allocated to the study of obesity, there is no consensus on its definition, causes, or solutions. Amidst ongoing debates over understandings of obesity, Obesity Canada (OC) was established to enhance the quality of life of Canadians with obesity through the advancement of anti-discrimination, policy change, and obesity prevention and treatment. Drawing upon a transdisciplinary social justice framework, we use critical thematic analysis to examine the OC website, which is the organization’s primary knowledge mobilization platform. (...) We will address the following research question: To what extent does OC serve social justice goals that promote the best interests of larger people? We argue that the social justice potential of OC ultimately falls short and conclude with some recommendations on how the site content could be enhanced with social justice principles. (shrink)

Commiserating with Devastated Things: Milan Kundera and the Entitlement of ThinkingWIRTHJASON M.fordham university press. 2016. pp. 227227. £54.00..

This essay traces the historicity of a single non-European literary critical idiom by addressing the modes in which “founding” and “subsequent” texts in literature and in criticism both form and interrupt the possibility of speaking of literature as an object. Focusing upon selected writings of Butros al-Bustani and Muhammad al-Muwaylihi , this essay considers the separations that attend the institutionalization of Arabic literary studies—between the old and the new, the modern and the classical, the secular and the religious, and more—and (...) that give literature to appear as an object of study even as they compel what is more idiomatic in literature to withdraw and disappear. (shrink)

In a finitary closure space, irreducible sets behave like two-valued models, with membership playing the role of satisfaction. If f is a function on such a space and the membership of in an irreducible set is determined by the presence or absence of the inputs in that set, then f is a kind of truth function. The existence of some of these truth functions is enough to guarantee that every irreducible set is maximally consistent. The closure space is then said (...) to be expressive. This paper identifies the two-valued truth functional conditions that guarantee expressiveness. (shrink)

Oliver Sacks MD, Clinical Professor of Neurology at the Albert Einstein College of Medicine in New York, talked with Anthony Freeman during his visit to London in January 1995 to publicize his recently published book An Anthropologist on Mars. The interview is preceded by an overview of the book.

Say that a property is topological if and only if it is invariant under homeomorphism. Homeomorphism would be a successful criterion for the equivalence of logical systems only if every logically significant property of every logical system were topological. Alas, homeomorphisms are sometimes insensitive to distinctions that logicians value: properties such as functional completeness are not topological. So logics are not just devices for exploring closure topologies. One still wonders, though, how much of logic is topological. This essay examines some (...) logically significant properties that are topological (or are topological in some important class). In the process, we learn something about the conditions under which the meaning of a connective can be "given by the connective's role in inference.". (shrink)

This case raises a number of complex ethical, legal, and practical issues, some of which cannot be resolved by a research ethics consultation. Sam is an adolescent who has end stage manifestations...

BackgroundCurrent guidelines do not clearly outline when assent should be attained from paediatric research participants, nor do they detail the necessary elements of the assent process. This stems from the fact that the fundamental justification behind the concept of assent is misunderstood. In this paper, we critically assess three widespread ethical arguments used for assent: children’s rights, the best interests of the child, and respect for a child’s developing autonomy. We then outline a newly-developed two-fold justification for the assent process: (...) respect for the parent’s pedagogical role in teaching their child to become an autonomous being and respect for the child’s moral worth.DiscussionWe argue that the ethical grounding for the involvement of young children in medical decision-making does not stem from children’s rights, the principle of best interests, or respect for developing autonomy. An alternative strategy is to examine the original motivation to engage with the child. In paediatric settings there are two obligations on the researcher: an obligation to the parents who are responsible for determining when and under what circumstances the child develops his capacity for autonomy and reasoning, and an obligation to the child himself. There is an important distinction between respecting a decision and encouraging a decision. This paper illustrates that the process of assent is an important way in which respect for the child as an individual can be demonstrated, however, the value lies not in the child’s response but the fact that his views were solicited in the first place.SummaryThis paper demonstrates that the common justifications for the process of assent are incomplete. Assent should be understood as playing a pedagogical role for the child, helping to teach him how specific decisions are made and therefore helping him to become a better decision-maker. How the researcher engages with the child supports his obligation to the child’s parents, yet why the researcher engages with the child stems from the child’s moral worth. Treating a child as having moral worth need not mean doing what they say but it may mean listening, considering, engaging or involving them in the decision. (shrink)

Bioscience ethics facilitates free and accurate information transfer from applied science to applied bioethics. Its major elements are: increased understanding of biological systems, responsible use of technology, and attuning ethnocentric debates to new scientific insights. Pioneered by Irina Pollard in 1994, bioscience ethics has become an internationally recognized discipline, interfacing science and bioethics within professional perspectives such as medical, legal, bio-engineering, and economics. Written for students and professionals alike, the fundamental feature of this book is its breadth, important because (...) bioscience ethics interweaves many diverse subjects in the process of gathering specialist scientific knowledge for bioethical review. It contains chapters which embrace topics affecting human reproduction, end-of-life care and euthanasia, challenge human-dominated ecosystems, and review population growth, economic activity and warfare. A background section describes the evolution of ethical consciousness, explores the future, and proposes that the reworking of ethical boundaries can enhance mature decision-making in harmony with changing technology. (shrink)

That mathematics makes for poor literature is a conclusion as uninteresting as it is inevitable—inevitable because were mathematical prose to score high on a scale of literary value, this result would do more to discredit the scale than glorify the prose. It may, however, help us better understand our cultural landscape if, without attempting a literary appraisal of mathematics or a mathematical appraisal of literature, we search for some community of interest between the formal sciences and the literary arts. This (...) search for common ground will also be an opportunity to learn from some voices seldom heard in conversations about mathematics. Even at the risk of giving our discussion an antiquated flavor, we will... (shrink)

“Bads” e.g. poverty, deprivation, constraint, ill-treatment, misery The traditional concern of theories of punishment (“retributive justice”).

This note examines the mereological component of Geoffrey Hellman's most recent version of modal structuralism. There are plausible forms of agnosticism that benefit only a little from Hellman's mereological turn.

In lieu of an abstract, here is a brief excerpt of the content:META-ONTOLOGY AND META-FICTION by Denis E. B. Pollard Peter van inwagen's attempt to explain the nature of fiction makes use of Quine's program in meta-ontology.1 This program comprises four basic theses: (i) that being is the same as existence, (ii) that being is univocal, (iii) that this univocal sense is best captured, for the purposes of formalization, by die existential quantifier, and (iv) that deciding what to believe (...) about what there is comes to a decision about what theories we should accept. As the aim of formalization is explicitness, then theories should be rendered into canonicalese and their commitments identified through those sentences which are prefaced with the existential quantifier. For Inwagen, as for his mentor Quine, acceptance of theory expressed in this canonical form entails acceptance of the ontology expressed in those quantified sentences. Bringing these considerations to bear on fiction, Inwagen asks, "What are theories about fiction?" and replies that they are "theories that treat stories as having an internal structure" (p. 72). The upshot of this is that such theories contain sentences which, when formally rendered, revead commitments to fictional objects. It is further claimed that such sentences can be vehicles of objective truth. Thus Inwagen finds he cannot wholeheartedly dismiss Sarah Gamp as a nonentity. In this respect, his view contrasts with two contemporary accounts, the "reductivist" one which denies Sarah Gamp's existence and her possession of any properties whatever, and the more recent "Meinongian" view which would agree that Sarah Gamp does not exist, but would nonetheless strenuously maintain that she is a nurse, fat, old, and decidedly the worse for drink. Inwagen's Sarah is neither ofthese: pace both these positions, she exists all right, but with properties such as being a theoretical entity of criticism, being a satiric villainess, not being a woman, and not being fond of gin. Inwagen's attempt to steer what seems to be a middle course has yielded, if anything, a more counterintuitive result than either ofthe other views. What is die explanation for this? 244 Denis E. B. Pollard245 To begin with, it is important to note a distinction, which Inwagen himself accepts, between two kinds of sentences. Let us take the following elementary examples: (1) "Sarah Gamp is a nurse," and (2) "Sarah Gamp is a character in a nineteenth-century novel." With specimens like (1), Inwagen sides with the reductivist: such sentences asefalse, and are not about anything. But it is with examples like (2) that ontology becomes a real issue, since sentences of this kind belong to literary theory. Neither authors nor critics who make use of sentences of the first kind are committed to the existence of fictional entities. So far, so good. But what is it that compels such commitment in the second case? Inwagen is sceptical about reductivist analyses which seek to paraphrase such sentences in order to remove any "misleading" implications. Such paraphrases he would regard as at best "messy," and more seriously, unlikely to preserve intuitive meaning without appearing to say that there are fictional characters. Unfortunately, he brushes this aside as a "narrow technical issue" at the very point where rather more argument is needed. However, on the issue of preservation of intuitive meaning, it might well be argued that his contention is somewhat question-begging, suggesting a rather literal reading of (2) above as a straightforward predication superficially akin to (3) "McEnroe is a seeded player in this year's Wimbledon tournament." So by a strange alchemy, the expression "Sarah Gamp" in (2) is accorded a referential status denied to it in (1). It is at this point that the notion of"theoretical entity" is introduced to supply the need for a referent dictated by the Quinean program. Inwagen's Sarah Gamp, in this theoretical disguise, can now literally satisfy predicates like "... is a character in a nineteenth-century novel," but not predicates like "... is a nurse." The parallel being exploited here is that with scientific theory. An ideal gas can satisfy Boyle's Law, but cannot literally be ignited, put into containers, or have an offensive smell. But there is more than a suspicion of equivocation over the term... (shrink)